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MEDI4166 efficiently suppresses PCSK9 and reduces LDL-cholesterol in cynomolgus monkey The effects of MEDI4166 on PCSK9 suppression, LDL-C level and the pharmacokinetic profile based on human GLP-1R activity and Fc detection, to determine in vivo peptide stability, were evaluated in healthy lean cynomolgus monkeys following a single intravenous (iv) dose at 1 or 5 mg/kg or subcutaneous (sc) dose at 10 or 100 mg/kg
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Results of bariatric surgery in 24 children/adolescents PWS compared to 72 non-PWS subjects matched for age, gender and BMI, undergoing a laparoscopic sleeve gastrectomy, have recently been published [107]
This test is not a predictor of exact medication response but may help contextualize why one formulation or dosing approach might align better with individual biology
